PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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Bromo-PEG1-C2-azide
0 ImagesBromo-PEG1-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG1-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Amino-PEG2-CH2CH2-SH hydrochloride
0 ImagesCat. No.: HY-132120CAS No.: 3037676-58-4
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N-Boc-diethanolamine
0 ImagesN-Boc-diethanolamine is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Hydroxy-PEG2-(CH2)2-Boc
0 ImagesHydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
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Aminooxy-PEG1-propargyl
0 ImagesCat. No.: HY-140056CAS No.: 1895922-69-6
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Tridecane-1,13-diol
0 ImagesCat. No.: HY-W105732CAS No.: 13362-52-2Synonyms: 1,13-Tridecanediol
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Benzyl N-(2-aminoethyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W008518CAS No.: 18807-71-1
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(4-(((tert-Butoxycarbonyl)amino)methyl)phenyl)boronic acid
0 ImagesCat. No.: HY-W076728CAS No.: 489446-42-6
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Ethyl 12-bromododecanoate
0 ImagesCat. No.: HY-W129255CAS No.: 72338-48-8
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2-(4-Bromobutyl)-1,3-dioxolane
0 ImagesCat. No.: HY-33316CAS No.: 87227-41-6
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trans-1,4-Cyclohexanediamine
0 ImagesCat. No.: HY-W007732CAS No.: 2615-25-0
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Fmoc-9-Aminononanoic acid
0 ImagesCat. No.: HY-W111228CAS No.: 212688-52-3Fmoc-9-aminononanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and and other conjugation applications. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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4-(2-Bromoethyl)phenol
0 ImagesCat. No.: HY-W004888CAS No.: 14140-15-9
